Anti-GDF5

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA015648.25	25 µl		-		7 - 10 business days*		300.00€
ATA-HPA015648.100	100 µl		-		7 - 10 business days*		421.00€

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Protein function: Growth factor involved in bone and cartilage formation. During cartilage... more

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Product information "Anti-GDF5"

Protein function: Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149, PubMed:21976273, PubMed:15530414, PubMed:25092592). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (PubMed:11276205). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 93% and to rat: 93%

Keywords:	Anti-GDF5, Anti-LAP-4, Anti-GDF-5, Anti-BMP14, Anti-CDMP-1, Anti-BMP-14, Anti-Radotermin, Anti-LPS-associated protein 4, Anti-Bone morphogenetic protein 14, Anti-Growth/differentiation factor 5, Anti-Lipopolysaccharide-associated protein 4
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA015648

Properties

Application:	IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: RYVFDISALE KDGLLGAELR ILRKKPSDTA KPAAPGGGRA AQLKLSSCPS GRQPASLLDV RSVPGLDGSG WEVFDIWKLF RNFKNSAQLC LELEAWERGR AVDL (ATA-APrEST72604)