Anti-GBP1

Protein function: Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Confers protection to several pathogens, including the bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii. Promotes IFN-gamma-mediated host defense against bacterial infections by regulating bacteriolytic peptide generation via its interaction with ubiquitin-binding protein SQSTM1, which delivers monoubiquitylated proteins to autolysosomes for the generation of bacteriolytic peptides. Exhibits antiviral activity against influenza virus (PubMed:22106366). [The UniProt Consortium]