Anti-gamma delta TCR1-N24 delta chain (bovine), clone GB21A

Anti-gamma delta TCR1-N24 delta chain (bovine), clone GB21A
Item number Size Datasheet Manual SDS Delivery time Quantity Price
WSC0578B-100 100 µg - -

3 - 8 business days*

223.00€
 
The monoclonal antibody was produced in cell culture. Protein function: Part of the TCR-CD3... more
Product information "Anti-gamma delta TCR1-N24 delta chain (bovine), clone GB21A"
The monoclonal antibody was produced in cell culture. Protein function: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells. [The UniProt Consortium]
Keywords: Anti-CD3d, Anti-CD3D, Anti-T-cell receptor T3 delta chain, Anti-T-cell surface glycoprotein CD3 delta chain
Supplier: Kingfisher Biotech
Supplier-Nr: WSC0578B

Properties

Application: FC, IHC, FA
Antibody Type: Monoclonal
Clone: GB21A
Conjugate: No
Host: Mouse
Reactivity: Bison, Bovine, Caprine, Water Buffalo
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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