Anti-G137B

similarity:Belongs to the GPR137 family.,tissue specificity:Expressed in kidney, heart, brain and placenta., Protein function: Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:31036939). Interacts with Rag GTPases and increases the lysosomial localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed:31036939). Involved in the regulation of lysosomal morphology and autophagy (PubMed:31036939). [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: Lysosome membrane , Multi-pass membrane protein . Colocalized with MTOR in lysosome after amino acid stimulation. .