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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-11-7008-25 | 25 µg | - |
3 - 11 business days* |
134.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Furin is a member of the PCs family (Pro-Hormone/Pro-Protein Convertase) of subtilisin-like... more
Product information "Anti-Furin"
Furin is a member of the PCs family (Pro-Hormone/Pro-Protein Convertase) of subtilisin-like endoproteinases. Furin along with PCs are intensively investigated as pharmacological targets for the treatment of many diseases, e.g., atherosclerosis, hypercholesterolaemia, and cancer, as well as viral and bacterial infections. Furin has been implicated in processing the Env (Envelope) proteins of human endogenous retroviruses, syncytins, the only possible fusogens known to be involved in placenta syncytialization, and therefore may participate in syncytin-mediated cell fusion in cells of both trophoblast and non-trophoblast lineages. Furin catalyzes proteolytic maturation of a diverse repertoire of growth factors, receptors, and enzyme precursors within multiple secretory pathway compartments. Proteolysis by furin is highly specific and occurs at C-terminal to a multibasic recognition motive. Furin is highly expressed in EVTs (Extravillous CTBs) and that furin function is required for trophoblast cell invasion into the maternal endometrium. Protein function: Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:7737999). [The UniProt Consortium]
Keywords: | Anti-FUR, Anti-PACE, Anti-Furin, Anti-FURIN, Anti-Dibasic-processing enzyme, Anti-Paired basic amino acid residue-cleaving enzyme, Polyclonal Antibody to Furin |
Supplier: | Abeomics |
Supplier-Nr: | 11-7008-25 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: mouse) |
Immunogen: | A partial length recombinant Furin protein (amino acids 602-791) was used as the immunogen for this antibody. |
Format: | Purified |
Database Information
KEGG ID : | K01349 | Matching products |
UniProt ID : | P09958 | Matching products |
Gene ID | GeneID 5045 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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