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This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined, however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. Protein function: DNA-binding transcription factor (PubMed:14506133, PubMed:14578375, PubMed:15277473, PubMed:16449236, PubMed:17210863, PubMed:19793056, PubMed:19279310, PubMed:25786029, PubMed:27804176). Upon DNA-binding, promotes DNA bending (PubMed:14506133). Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (PubMed:17993506). [The UniProt Consortium]
Keywords:
Anti-FOXC1, Anti-FKHL7, Anti-FREAC-3, Anti-Forkhead box protein C1, Anti-Forkhead-related protein FKHL7, Anti-Forkhead-related transcription factor 3, FOXC1 Polyclonal Antibody
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