Anti-Formin-like protein 2

Formin-like protein 2/FHOD1 (formin homology 2 domain containing 1) acts as a capping and bundling protein. In cells, active FHOD1 stimulates the formation of ventral stress fibers. FHOD1 is mainly located at the intercalated disc, the special type of cell-cell contact between cardiomyocytes (25125170).FHOD1 promotes the formation of short actin filaments and transiently associates with transverse arcs, thus providing tight temporal and spatial control of the formation and turnover of transverse arcs into mature ventral stress fibers during dynamic cell behavior (24481812). Protein function: Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. [The UniProt Consortium]