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You can also order by e-mail: info@biomol.com
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that... more
Product information "Anti-FMO3"
Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimet Protein function: Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds (PubMed:9224773). [The UniProt Consortium]
Keywords: | Anti-FMO3, Anti-FMO 3, Anti-FMO II, Anti-FMO form 2, EC=1.14.13.8, EC=1.14.13.148, Anti-Dimethylaniline oxidase 3, Anti-Trimethylamine monooxygenase, Anti-Hepatic flavin-containing monooxygenase 3, Anti-Dimethylaniline monooxygenase [N-oxide-forming] 3, F |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-60495 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Recombinant protein of human FMO3 |
Database Information
KEGG ID : | K00485 | Matching products |
UniProt ID : | P31513 | Matching products |
Gene ID | GeneID 2328 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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