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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-20-1065-50 | 50 µl | - |
3 - 11 business days* |
373.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This antibody recognizes FLIP long and short, isoforms that contain the peptide immunogen... more
Product information "Anti-FLIP"
This antibody recognizes FLIP long and short, isoforms that contain the peptide immunogen sequence (DRKAVETHLLRNPHLVSD). Human FLIP is a 480 amino acid protein which contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and 10, and potently inhibits apoptosis induced by death receptors.However, the functions of FLIP remain to be fully elucidated and there is some evidence FLIP may also act as an activator of caspase-8/-10 in certain cases, thereby taking on an apoptosis promoting role.Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the caspase (ICE/CED-3) protease family. Most if not all, forms of apoptosis involve activation of the caspases. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the caspase family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively. The human FLIP was also cloned by several labs independently and termed Casper , I-FLICE, FLAME-1, CASH and CLARP3-7. Protein function: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. [The UniProt Consortium]
Keywords: | Anti-CASH, Anti-CFLAR, Polyclonal antibody to FLIP |
Supplier: | Abeomics |
Supplier-Nr: | 20-1065 |
Properties
Application: | IP, IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: mouse) |
Immunogen: | A synthetic peptideof human FLIP (amino acids 75-92 DRKAVETHLLRNPHLVS) was used as immunogen for this antibody |
Format: | Sera |
Database Information
KEGG ID : | K04724 | Matching products |
UniProt ID : | O15519 | Matching products |
Gene ID | GeneID 8837 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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