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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
F4550-05B.50 | 50 µl | - | - |
3 - 19 business days* |
490.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Cell death signals are transduced by death domain (DD)- containing adapter molecules and members... more
Product information "Anti-FLIP (CASP8 and FADD-like Apoptosis Regulator, Caspase Homolog, CASH, Caspase-eight-related Pro"
Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the caspase (ICE/CED-3) protease family. Most if not all, forms of apoptosis involve activation of the caspases. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the caspase family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively. The human FLIP was also cloned by several labs independently and termed Casper , I-FLICE, FLAME-1, CASH and CLARP3-7. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and 10, and potently inhibits apoptosis induced by death receptors (reviewed in Peter, 2004). However, the functions of FLIP remain to be fully elucidated and there is some evidence FLIP may also act as an activator of caspase-8/-10 in certain cases, thereby taking on an apoptosis promoting role. FLIP has a short form and a long form. Additionally, four splice variants of c-FLIPs have been identified and termed FLIP a, b, g, and d. IMG-5728 recognizes FLIP. Human FLIP long is a 480 amino acid protein, GenBank no. gi12643547. Human FLIP short is a 221 amino acid protein, GenBank no. AAC51623.1. This antibody will recognize FLIP long and short, and FLIP isoforms that contain the peptide immunogen sequence (DRKAVETHLLRNPHLVSD), including FLIP a, b, g, and d. Applications: Suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation. Other applications not tested. Recommended Dilution: Western Blot: 1:1000-1:2000, Immunohistochemistry (formalin fixed paraffin embedded): 1:1000-1:5000, Immunoprecipitation: 1:50-1:200, Immunohistochemistry: Frozen, Optimal dilutions to be determined by the researcher. Positive Control: CNS, lymphatic tissues, many cancer cell lines, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-Caspase homolog, Anti-Caspase-eight-related protein, Anti-MACH-related inducer of toxicity, Anti-FADD-like antiapoptotic molecule 1, Anti-Cellular FLICE-like inhibitory protein, Anti-CASP8 and FADD-like apoptosis regulator |
Supplier: | United States Biological |
Supplier-Nr: | F4550-05B |
Properties
Application: | IHC, IP, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic peptide corresponding to aa75-92 (DRKAVETHLLRNPHLVS) of human FLIP |
Format: | Serum |
Database Information
KEGG ID : | K04724 | Matching products |
UniProt ID : | O15519 | Matching products |
Gene ID | GeneID 8837 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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