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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES2346.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES2346.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
function:Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response... more
Product information "Anti-FIR"
function:Rho-guanine nucleotide exchange factor that activates RAC1. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 FERM domain.,similarity:Contains 2 PH domains.,subunit:Interacts with PLXNA1. Interaction with PLXNA1 or PIP5K1C lowers its guanine nucleotide exchange activity. Dissociates from PLXNA1 when SEMA3A binds to the receptor. Interacts with PIP5K1C via its FERM domain. The interaction with PIP5K1C is enhanced by SEMA3A binding., Protein function: Functions as guanine nucleotide exchange factor that activates RAC1. May have relatively low activity. Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion. [The UniProt Consortium] Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.. Cellular localization: cytoplasm,cytosol,cytoskeleton,extrinsic component of membrane,
Keywords: | Anti-FIR, Anti-FARP2, Anti-KIAA0793, Anti-FERM domain-including RhoGEF, Anti-PH domain-containing family C member 3, Anti-FERM, ARHGEF and pleckstrin domain-containing protein 2, Anti-FERM, RhoGEF and pleckstrin domain-containing protein 2, FIR rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES2346 |
Properties
Application: | WB, IF, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | The antiserum was produced against synthesized peptide derived from human FIR. AA range:331-380 |
MW: | 119 kD |
Format: | Antiserum |
Database Information
KEGG ID : | K06082 | Matching products |
UniProt ID : | O94887 | Matching products |
Gene ID | GeneID 9855 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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