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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES16482.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES16482.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell... more
Product information "Anti-FGD4"
This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015], Protein function: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000. Cellular localization: Cytoplasm, cytoskeleton . Cell projection, filopodium . Concentrated in filopodia and poorly detected at lamellipodia. Binds along the sides of actin fibers (By similarity). .
Keywords: | Anti-FGD4, Anti-FRABP, Anti-FGD1-related F-actin-binding protein, Anti-Actin filament-binding protein frabin, Anti-Zinc finger FYVE domain-containing protein 6, Anti-FYVE, RhoGEF and PH domain-containing protein 4, FGD4 rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES16482 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Synthesized peptide derived from human FGD4 AA range: 291-341 |
MW: | 85 kD |
Format: | Purified |
Database Information
KEGG ID : | K05723 | Matching products |
UniProt ID : | Q96M96 | Matching products |
Gene ID | GeneID 121512 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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