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| Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
|---|---|---|---|---|---|---|---|
| G-CAB18122.50 | 50 µl | - | - |
9 - 20 business days* |
352.00€
|
||
| G-CAB18122.100 | 100 µl | - |
9 - 20 business days* |
448.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Substrate-recognition component of a Cul7-RING ubiquitin- protein ligase... more
Product information "Anti-FBXW8"
Protein function: Substrate-recognition component of a Cul7-RING ubiquitin- protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7- RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:18498745). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (PubMed:24362026). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (PubMed:24793695). [The UniProt Consortium]
| Keywords: | Anti-FBW6, Anti-FBXW8, Anti-F-box only protein 29, Anti-F-box/WD repeat-containing protein 8, Anti-F-box and WD-40 domain-containing protein 8, FBXW8 Rabbit pAb |
| Supplier: | Assay Genie |
| Supplier-Nr: | CAB18122 |
Properties
| Application: | WB, IF |
| Antibody Type: | Polyclonal |
| Conjugate: | No |
| Host: | Rabbit |
| Species reactivity: | human, mouse, rat |
Database Information
| KEGG ID : | K10264 | Matching products |
| UniProt ID : | Q8N3Y1 | Matching products |
| Gene ID | GeneID 26259 | Matching products |
Handling & Safety
| Storage: | +4°C |
| Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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