Anti-FBXO38

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA034821.25	25 µl		-		7 - 10 business days*		335.00€
ATA-HPA034821.100	100 µl		-		7 - 10 business days*		446.00€

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Protein function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3... more

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Product information "Anti-FBXO38"

Protein function: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1, the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 96% and to rat: 99%

Keywords:	Anti-SP329, Anti-F-box only protein 38
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA034821

Properties

Application:	ICC, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: YTLEGVVDGA PYSMISDFPW LRSLRAAEPN SFARYDFEDD EESTIYAPRR KGQLSADICM ETIGEEISEM RQMKKGVFQR VVA (ATA-APrEST80883)