Anti-FAT2

This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008], Protein function: Involved in the regulation of cell migration (PubMed:18534823). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development. [The UniProt Consortium] Recommended dilutions: IHC-p 1:50-300. Cellular localization: Cell membrane , Single-pass type I membrane protein . Cell junction . Golgi apparatus, trans-Golgi network . Localized at adhesion zippers (early state of adherens junctions) of keratinocytes. .