Anti-Fascin

Anti-Fascin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-R30651 100 µg - -

3 - 10 business days*

549.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Fascin is a actin cross-linking protein.... more
Product information "Anti-Fascin"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Fascin is a actin cross-linking protein. The gene contains 5 exons and spans 7 kb. It is a 54-58 kilodalton monomeric actin filament bundling protein originally isolated from sea urchin egg but also found in Drosophila and vertebrates, including humans. Fascin is spaced at 11 nanometre intervals along the filament. The bundles in cross section are seen to be hexagonally packed, and the longitudinal spacing is compatible with a model where fascin cross-links at alternating 4 and 5 actins. It is calcium insensitive and monomeric. Fascin binds beta-catenin, and colocalizes with it at the leading edges and borders of epithelial and endothelial cells. The role of Fascin in regulating cytoskeletal structures for the maintenance of cell adhesion, coordinating motility and invasion through interactions with signalling pathways is an active area of research especially from the cancer biology perspective. Abnormal fascin expression or function has been implicated in breast cancer, colon cancer, esophageal squamous cell carcinoma, gallbladder cancer and prostate cancer. Protein function: Organizes filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. [The UniProt Consortium]
Keywords: Anti-p55, Anti-FAN1, Anti-FSCN1, Anti-Fascin, Anti-Singed-like protein, Anti-55 kDa actin-bundling protein, Fascin Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: R30651

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: An amino acid sequence from the N-terminus of human Fascin (DDGRWSLQSEAHRRYFG) was used as the immunogen for this Fascin antibody (100% homologous in human, mouse and rat).
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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