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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V3967SAF-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
1 mg/ml in 1X PBS, BSA free, sodium azide free. In contrast to growth factors which promote cell... more
Product information "Anti-FAF1 / FAS-associated factor 1, clone CPTC-FAF1-2"
1 mg/ml in 1X PBS, BSA free, sodium azide free. In contrast to growth factors which promote cell proliferation, FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved death domain and belonging to the TNF receptor superfamily. TRADD, FADD and RIP are FAS/TNF-RI interacting proteins that contain a death domain homologous region (DDH). TRADD (TNF-RI-associated death domain) and FADD (FAS-associated death domain) associate with the death domains of both FAS and TNF-RI via their DDH regions, while RIP associates exclusively with FAS. An additional FAS interacting protein designated FAF1, for FAS-associated protein factor-1, binds with the cytoplasmic tail of wildtype but not LPR mutant FAS. When overexpressed in cells, FAF1 enhances the efficiency of FAS-mediated apoptosis. In contrast to TRADD, FADD and RIP, FAF1 lacks a DDH and cannot induce apoptosis independently of FAS activation. Protein function: Ubiquitin-binding protein (PubMed:19722279). Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564). Potentiates but cannot initiate FAS-induced apoptosis. [The UniProt Consortium]
Keywords: | Anti-FAF1, Anti-hFAF1, Anti-UBXD12, Anti-CGI-03, Anti-FAS-associated factor 1, Anti-UBX domain-containing protein 12, Anti-UBX domain-containing protein 3A, FAF1 Antibody / FAS-associated factor 1 |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V3967SAF |
Properties
Application: | IHC (paraffin), WB |
Antibody Type: | Monoclonal |
Clone: | CPTC-FAF1-2 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant full length human protein |
Format: | Purified |
Database Information
KEGG ID : | K20703 | Matching products |
UniProt ID : | Q9UNN5 | Matching products |
Gene ID | GeneID 11124 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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