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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-F47446-0.08ML | 80 µl | - | - |
3 - 10 business days* |
326.00€
|
||
NSJ-F47446-0.4ML | 400 µl | - | - |
3 - 10 business days* |
702.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
In 1X PBS, pH 7.4, with 0.09% sodium azide. The protein encoded by this gene is an adaptor... more
Product information "Anti-FADD"
In 1X PBS, pH 7.4, with 0.09% sodium azide. The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. Protein function: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. [The UniProt Consortium]
Keywords: | Anti-FADD, Anti-GIG3, Anti-MORT1, Anti-Protein FADD, Anti-Growth-inhibiting gene 3 protein, Anti-FAS-associated death domain protein, Anti-Mediator of receptor induced toxicity, Anti-FAS-associating death domain-containing protein, FADD Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | F47446 |
Properties
Application: | WB, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | A portion of amino acids 106-135 from the human protein was used as the immunogen for this FADD antibody. |
Format: | Purified |
Database Information
KEGG ID : | K02373 | Matching products |
UniProt ID : | Q13158 | Matching products |
Gene ID | GeneID 8772 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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You will get a certificate here
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