Anti-FABP6 Rabbit Monoclonal (Clone 201)

Fatty acid-binding protein 6 (FABP6) is a member of the intracellular lipid-binding protein (iLBP) family with a role in bile acid homeostasis. It is composed of 10 antiparallel beta-strands, which form a beta-barrel containing a lipid binding site and is expressed primarily in enterocytes of the ileum, and to a lesser extent in the adrenal gland, ovaries, and stomach. FABP6 binds bile acids and fatty acids and interacts with the ileal bile acid transporter to aid in bile acid uptake and facilitate intracellular trafficking of bile acids. Fabp6 knockdown induces dietary fat malabsorption, decreased bile acid reabsorption, and a sex-specific increase in adiposity in mice fed a Western diet. Serum levels of FABP6 are increased in patients with colorectal cancer and decrease following surgical removal of cancerous tissues. FABP6T79M is associated with a decreased risk of type 2 diabetes in obese individuals. Cayman's FABP6 Rabbit Monoclonal Antibody (Clone 201) can be used for flow cytometry (FC), immunocytochemistry (ICC), and immunofluorescence (IF) applications.Synonyms: Fatty Acid-binding Protein 6, I-BALB, Ileal Lipid-binding Protein, ILLBP, Intestinal Bile Acid-binding Protein. Immunogen: Recombinant human FABP6. Clone Designation: 201. Formulation: (Request formulation change), 50 or 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: 0.2 µm filtered solution in PBS. Host: Rabbit. Isotype: IgG. Applications: FC, ICC, IF.