Anti-FABP4

Fatty acid binding protein 4 (FABP4) is a member of the intracellular lipid-binding protein (iLBP) family. It is composed of a beta-barrel, which forms the lipid-binding site, and two alpha-helices that form a lid on the beta-barrel. FABP4 is primarily expressed in adipocytes but has also been found in activated macrophages. It is involved in lipid transport and metabolism, insulin resistance, and angiogenesis, and its expression is induced by long-chain fatty acids and peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. Knockout of Fabp4 prevents the development of atherosclerosis in ApoE-/- mice and increases body weight gain and insulin sensitivity in ob/ob mice. Serum levels of FABP4 are increased in patients with colorectal cancer, and serum and synovial fluid levels of FABP4 are increased in patients with rheumatoid arthritis. Cayman's FABP4 Polyclonal Antibody can be used for immunofluorescence (IF), immunohistochemistry (IHC), and Western blot (WB) applications.Synonyms: Adipocyte FABP, A-FABP, ALBP, aP2, Fatty Acid Binding Protein 4. Immunogen: Synthetic peptide from the C-terminal region of human FABP4. Formulation: (Request formulation change), Peptide affinity-purified IgG. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: IF, IHC, WB. Cross Reactivity: (-) FABP3, (-) FABP5, (+) FABP4. UniProt Accession #: P15090. Origin: Animal/Rabbit.