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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES2288.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES2288.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding... more
Product information "Anti-ERAP1"
The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010], Protein function: Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. [The UniProt Consortium] Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.. Cellular localization: Endoplasmic reticulum membrane , Single-pass type II membrane protein .
Keywords: | Anti-ERAP1, Anti-A-LAP, Anti-ARTS-1, Anti-APPILS, Anti-PILS-AP, EC=3.4.11.-, Anti-Aminopeptidase PILS, Anti-Endoplasmic reticulum aminopeptidase 1, Anti-Adipocyte-derived leucine aminopeptidase, Anti-Puromycin-insensitive leucyl-specific aminopeptidase, E |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES2288 |
Properties
Application: | WB, IHC, IF, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | The antiserum was produced against synthesized peptide derived from human ARTS-1. AA range:441-490 |
MW: | 107 kD |
Format: | Antiserum |
Database Information
KEGG ID : | K09604 | Matching products |
UniProt ID : | Q9NZ08 | Matching products |
Gene ID | GeneID 51752 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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