Anti-EphA2, clone 66G9

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG57080.50 50 µl - -

6 - 14 business days*

488.00€
 
Protein function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A... more
Product information "Anti-EphA2, clone 66G9"
Protein function: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand- independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis. [The UniProt Consortium]
Keywords: Anti-ECK, Anti-EPHA2, EC=2.7.10.1, Anti-Epithelial cell kinase, Anti-Ephrin type-A receptor 2, Anti-Tyrosine-protein kinase receptor ECK
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG57080

Properties

Application: WB, FC
Antibody Type: Monoclonal
Clone: 66G9
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Recombinant fragment around aa. 27-537 of Human EphA2
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
or to request a certificate of analysis.
Read, write and discuss reviews... more
Customer review for "Anti-EphA2, clone 66G9"
Write a review
or to review a product.
Viewed