Anti-Endothelial Lipase

Endothelial lipase (EL) is a major genetic determinant for the concentration, structure, and metabolism of high-density lipoprotein, which protects against atherosclerosis.{11500, 11501} It was originally cloned from endothelial cells and found to be expressed in a distinct and complementary tissue-restricted fashion, with high-level expression in the liver, placenta, lung, ovary, and macrophage. Immunohistochemical studies demonstrate that EL is expressed in infiltrating cells such as macrophages within atheromatous plaques, in addition to endothelial and smooth muscle cells in non-atherosclerotic coronary arteries. Furthermore, EL expression is detected in the neovasculature within atheromatous plaques in atherosclerotic coronary arteries, indicating that EL may have unique functional roles in atherosclerosis. Cayman Chemical's EL polyclonal antibody can be used for western blot and immunohistochemical analysis for EL on samples of human, murine, rat, porcine, and ovine origin. Other applications for use of this antibody have not yet been tested.Synonyms: EL, EDL. Immunogen: Synthetic peptide from the N-terminal region of human endothelial lipase. Formulation: (Request formulation change), 500 µl of peptide affinity-purified polyclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol, 0.5 mg/ml BSA, and 0.02% sodium azide. Host: Rabbit. Applications: IHC, WB. UniProt Accession #: Q9Y5X9. Origin: Animal/Rabbit.