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The protein encoded by this gene has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Protein function: Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. [The UniProt Consortium]
Keywords:
Anti-HPC2, Anti-ELAC2, Anti-RNase Z 2, Anti-tRNase Z 2, EC=3.1.26.11, Anti-Ribonuclease Z 2, Anti-tRNA 3 endonuclease 2, Anti-ElaC homolog protein 2, Anti-Heredity prostate cancer protein 2, Anti-Zinc phosphodiesterase ELAC protein 2, ELAC2 Polyclonal Ant
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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