Anti-EIF6

0.5mg/ml if reconstituted with 0.2ml sterile DI water. EIF6 (Eukaryotic Translation Initiation Factor 6), also called ITGB4BP, is a human gene. By fluorescence in situ hybridization, Sanvito et al.(1998) mapped the gene to 20q11.2. Ceci et al.(2003) demonstrated that the ribosomal 60S subunit is activated by release of EIF6. In the cytoplasm, it is bound to free 60S but not to 80S subunits. Furthermore, the protein interacts in the cytoplasm with RACK1, a receptor for activated protein kinase C. Gandin et al.(2008) demonstrated that the protein is required for efficient initiation of translation in vivo. Null mouse embryos were lethal at preimplantation. Heterozygous mice had 50% reduction of EIF6 levels in all tissues, and showed reduced mass of hepatic and adipose tissues due to a lower number of cells and to impaired G1/S cell cycle progression. Protein function: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May behave as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (GNB2L1)-dependent protein kinase C activity. [The UniProt Consortium]