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This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. Protein function: Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). [The UniProt Consortium]
Keywords:
DSTYK, SgK496, Dusty PK, KIAA0472, HDCMD38P, EC=2.7.12.1, Sugen kinase 496, Dusty protein kinase, RIP-homologous kinase, Dual serine/threonine and tyrosine protein kinase, Receptor-interacting serine/threonine-protein kinase 5, DSTYK Polyclonal Antibody
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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