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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES9591.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES9591.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
domain:The N-terminal 240 amino acids are sufficient to mediate complex formation.,function:May... more
Product information "Anti-DPOA2"
domain:The N-terminal 240 amino acids are sufficient to mediate complex formation.,function:May play an essential role at the early stage of chromosomal DNA replication by coupling the polymerase alpha/primase complex to the cellular replication machinery.,PTM:Phosphorylated in a cell cycle-dependent manner, in G2/M phase.,similarity:Belongs to the DNA polymerase alpha subunit B family.,subunit:DNA polymerase alpha:primase is a four subunit enzyme complex, which is assembled throughout the cell cycle, and consists of the two DNA polymerase subunits A and B, and the DNA primase large and small subunits. Subunit B binds to subunit A., Protein function: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (PubMed:9705292). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: Nucleus.
Keywords: | Anti-POLA2, Anti-DNA polymerase alpha subunit B, Anti-DNA polymerase alpha 70 kDa subunit, DPOA2 rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES9591 |
Properties
Application: | WB, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, rat, mouse, |
Immunogen: | Synthesized peptide derived from part region of human protein |
MW: | 65 kD |
Format: | Purified |
Database Information
KEGG ID : | K02321 | Matching products |
UniProt ID : | Q14181 | Matching products |
Gene ID | GeneID 23649 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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