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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-R30979 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Discoidin domain receptor family, member... more
Product information "Anti-DDR2"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Discoidin domain receptor family, member 2, also known as NTRKR3 or TKT, is a human gene. DDR2 protein was detected in most mouse tissues examined. Highest levels of phosphorylated protein were detected in lung, ovary, and skin, which did not correlate with DDR2 protein levels. The gene is mapped 1q23.3. DDRs play a key role in the communication of cells with their microenvironment. Using in situ hybridization with 1-week-old mice, Labrador et al.(2001) found that DDR2 was expressed along chondrocyte columns in the proliferative region of the growth plate. mRNA was also present, although dispersed, at areas of calcified cartilage in the cartilage-bone junction, as well as in the trabecular bone surface. Bargal et al.(2009) also identified a splice site mutation in the gene, which resulted in the skipping of exon 17, in one of the Jewish families with SMED-SL originally reported by Borochowitz et al.(1993). Protein function: Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing. [The UniProt Consortium]
Keywords: | Anti-DDR2, Anti-NTRKR3, Anti-CD167b, EC=2.7.10.1, Anti-Discoidin domain receptor 2, Anti-Tyrosine-protein kinase TYRO10, Anti-CD167 antigen-like family member B, Anti-Receptor protein-tyrosine kinase TKT, Anti-Discoidin domain-containing receptor 2, DDR2 |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | R30979 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | An amino acid sequence from the C-terminus of human DDR2 (RDTKNRPSFQEIHLLLLQQGDE) was used as the immunogen for this DDR2 antibody. |
Format: | Purified |
Database Information
KEGG ID : | K05125 | Matching products |
UniProt ID : | Q16832 | Matching products |
Gene ID | GeneID 4921 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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