Anti-DDI2

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA043119.25	25 µl		-		7 - 10 business days*		335.00€
ATA-HPA043119.100	100 µl		-		7 - 10 business days*		446.00€

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Protein function: Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104',... more

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Product information "Anti-DDI2"

Protein function: Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27676298, PubMed:27528193). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2 (Probable). Required, with DDI1, for cellular survival following replication stress. Together or redudantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (PubMed:29290612). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 93% and to rat: 84%

Keywords:	Anti-Protein DDI1 homolog 2
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA043119

Properties

Application:	WB, IHC, ICC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: EGELPECARL AYGAGREDVR PEEIADQELA EALQKSAEDA ERQKP (ATA-APrEST83634)