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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-RQ5519 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Deleted in Colorectal Carcinoma, also... more
Product information "Anti-DCC / Deleted in Colorectal Carcinoma"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Deleted in Colorectal Carcinoma, also known as DCC, is a protein which in humans is encoded by the DCC gene. It is mapped to 18q21.2. This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. Protein function: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. [The UniProt Consortium]
Keywords: | Anti-DCC, Anti-IGDCC1, Anti-Netrin receptor DCC, Anti-Colorectal cancer suppressor, Anti-Tumor suppressor protein DCC, Anti-Immunoglobulin superfamily DCC subclass member 1, DCC Antibody / Deleted in Colorectal Carcinoma |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | RQ5519 |
Properties
Application: | WB, IHC (paraffin), Direct ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | A human recombinant protein (amino acids Q851-F1447) |
Format: | Purified |
Database Information
KEGG ID : | K06765 | Matching products |
UniProt ID : | P43146 | Matching products |
Gene ID | GeneID 1630 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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