Anti-Cytokeratin, Basic (Type II or HMW) (Epithelial Marker) (clone: KRTH/1576R) (recombinant rabbit

This MAb recognizes basic (Type II or HMW) cytokeratins, which include 67kDa (CK1), 64kDa (CK3), 59kDa (CK4), 58kDa (CK5), 56kDa (CK6), 52kDa (CK8). Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50 , 48, 46, 45, and 40kDa. MAb AE3 recognizes the 65-67, 64, 59, 58, 56, and 52kDa keratins of basic subfamily. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. Protein function: Probably contributes to terminal cornification. [The UniProt Consortium]