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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
C8855-01B.100 | 100 µg | - | - |
3 - 19 business days* |
978.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Cyclophilin B is a 24kD glycoprotein member of the B subfamily of the cyclophilin-type PPIase... more
Product information "Anti-Cyclophilin B (PPIB, peptidylpropyl isomerase B)"
Cyclophilin B is a 24kD glycoprotein member of the B subfamily of the cyclophilin-type PPIase family of molecules. It is both secreted and retained in the ER. When secreted, Cyclophilin B mediates chemotaxis and T cell adhesion to fibronectin. This is likely due to its prolyl cis/trans isomerase activity. Intracellularly, Cyclophilin B appears to serve as a molecular chaperone for molecules destined for secretion. It does so via stabilization, and facilitating the activity of additional chaperones. The human Cyclophilin B precursor is 216 amino acids (aa) in length. It contains a 25aa signal sequence plus a 191aa mature region. There is a partial heparin-binding sequence (aa27-34), a PPIase domain (aa47-204) and a C-terminal ER retention motif (aa213-216)., , Applications:, Suitable for use in Western Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1ug/ml detects Cyclophilin B in HeLa human cervical epithelial carcinoma cell line, A431 human epithelial carcinoma cell line, BaF3 mouse pro-B cell line, PC-12 rat adrenal pheochromocytoma cell line, Rat-2 rat embryonic fibroblast cell line and NRK rat normal kidney cells., Immunocytochemistry: 8-25ug/ml. Immersion fixed HeLa human cervical epithelial carcinoma cell line, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-CYPB, Anti-SCYLP, EC=5.2.1.8, Anti-CYP-S1, Anti-PPIase B, Anti-Rotamase B, Anti-S-cyclophilin, Anti-Peptidyl-prolyl cis-trans isomerase B |
Supplier: | United States Biological |
Supplier-Nr: | C8855-01B |
Properties
Application: | ICC, WB |
Antibody Type: | Monoclonal |
Clone: | 9H108 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, mouse, rat |
Immunogen: | Purified, E. coli-derived recombinant human Cyclophilin B (rhCyclophilin B, aa 34-216, Accession# P23284). |
Format: | Affinity Purified |
Database Information
KEGG ID : | K03768 | Matching products |
UniProt ID : | P23284 | Matching products |
Gene ID | GeneID 5479 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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