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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-30-1084-0.1 | 100 µg | - |
3 - 11 business days* |
580.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Cyclin D1 (PRAD1, Bcl-1) is a cytoplasmic and nuclear protein, which is synthesized during G1... more
Product information "Anti-Cyclin D1 Monoclonal Antibody (Clone:DCS-6)"
Cyclin D1 (PRAD1, Bcl-1) is a cytoplasmic and nuclear protein, which is synthesized during G1 phase and assembles with either cyclin-dependent kinase 4 (CDK4) or CDK6 in response to growth factor stimulation. D-type cyclin-CDK complexes act to inactivate the growth-suppressive function of the Rb protein through its phosphorylation, and titrate CDK inhibitors such as p21Cip1 and p27Kip1. Whereas during G1 phase cyclin D1 accumulates in the nucleus, it translocates into the cytoplasm during S phase. Without growth factor-mediated stimulation cyclin D1 is unstable, and undergoes ubiquitin-mediated degradation, which is triggered by its phosphorylation. Cyclin D1 destabilization participates in G1/S phase arrest. Protein function: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). In vitro catalyzes 'Lys-48'-linked polyubiquitination (PubMed:20061386). Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1 (PubMed:18042044, PubMed:18359941). Ubiquitinates STUB1-associated HSP90AB1 in vitro (PubMed:18042044). Lacks inherent specificity for any particular lysine residue of ubiquitin (PubMed:18042044). Essential for viral activation of IRF3 (PubMed:19854139). Mediates polyubiquitination of CYP3A4 (PubMed:19103148). [The UniProt Consortium]
Keywords: | Anti-SFT, Anti-UbcH5, Anti-UBE2D1, Anti-UBC4/5 homolog, Anti-Stimulator of Fe transport, Anti-Ubiquitin-protein ligase D1, Anti-Ubiquitin carrier protein D1, Anti-Ubiquitin-conjugating enzyme E2 D1, Anti-E2 ubiquitin-conjugating enzyme D1, Anti-Cyclin D1 |
Supplier: | Abeomics |
Supplier-Nr: | 30-1084 |
Properties
Application: | FC, IP, WB, IHC, IHC (frozen), ICC, FA |
Antibody Type: | Monoclonal |
Clone: | DCS-6 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human, non-human primates, mouse, rat |
Immunogen: | recombinant human cyclin D1 (amino acids 1-295) |
Format: | Affinity Purified |
Database Information
KEGG ID : | K06689 | Matching products |
UniProt ID : | P51668 | Matching products |
Gene ID | GeneID 7321 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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