Anti-CSK, C-terminal

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG63445.100 100 µg - -

6 - 14 business days*

586.00€
 
Protein function: Non-receptor tyrosine-protein kinase that plays an important role in the... more
Product information "Anti-CSK, C-terminal"
Protein function: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. [The UniProt Consortium]
Keywords: Anti-CSK, EC=2.7.10.2, Anti-C-Src kinase, Anti-Protein-tyrosine kinase CYL, Anti-Tyrosine-protein kinase CSK
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG63445

Properties

Application: ELISA, IHC (paraffin), WB
Antibody Type: Polyclonal
Conjugate: No
Host: Goat
Reactivity: Human, Mouse, Rat (Expected: Canine, Bovine)
Immunogen: C-EQLEHIKTHELHL
Format: Ammonium Sulfate Precipitated

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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