Anti-Csk, clone CSK-04

Anti-Csk, clone CSK-04
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG62966.50 50 µl - -

6 - 14 business days*

351.00€
ARG62966.100 100 µl - -

6 - 14 business days*

505.00€
 
Protein function: Non-receptor tyrosine-protein kinase that plays an important role in the... more
Product information "Anti-Csk, clone CSK-04"
Protein function: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK. [The UniProt Consortium]
Keywords: Anti-CSK, Anti-C-Src kinase, Anti-Tyrosine-protein kinase CSK, Anti-Protein-tyrosine kinase CYL
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG62966

Properties

Application: WB, IP, ICC, IF
Antibody Type: Monoclonal
Clone: CSK-04
Conjugate: No
Host: Mouse
Reactivity: Human, Mouse
Immunogen: Bacterially expressed recombinant fragment of human Csk corresponding to aa 330-450
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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