Anti-CR2/CD21 (C-Term) Rabbit Monoclonal Antibody (Clone RM372)

Complement receptor 2 (CR2), also known as CD21, is a type I transmembrane glycoprotein with a role in the complement system. It is composed of an extracellular domain that contains 15 or 16 short consensus repeats involved in stabilizing the triple-loop domain conformation, a transmembrane domain, and a short cytoplasmic domain containing one PKC and one tyrosine kinase phosphorylation site. CR2 is primarily expressed on mature B cells and follicular dendritic cells (FDCs) but is also expressed on the pharyngeal and cervical epithelium, thymocytes, and a subset of peripheral T cells. It forms a complex with CD19, TAPA-1, and Leu-19 on the surface of B cells, where it acts as a ligand-fixing subunit that binds surface-fixed cleavage fragments of complement protein C3 on antigen presenting cells to amplify antigen-induced B cell activation and antibody production. CR2 is also a receptor for Epstein Barr Virus. B cell levels of CR2 are decreased in patients with systemic lupus erythematosus (SLE). Cayman's CR2/CD21 (C-Term) Rabbit Monoclonal Antibody (Clone RM372) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: Complement Receptor 2, Epstein Barr Virus Receptor, Complement C3d Receptor, C3DR. Immunogen: Peptide from the C-terminal region of human CR2. Clone Designation: RM372. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) CR2.