Anti-COX4I1 / COX IV-1, clone AIC-3

Anti-COX4I1 / COX IV-1, clone AIC-3
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-RQ5400 100 µl - -

3 - 10 business days*

755.00€
 
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. Cytochrome c oxidase... more
Product information "Anti-COX4I1 / COX IV-1, clone AIC-3"
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. [RefSeq] Protein function: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol- cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. [The UniProt Consortium]
Keywords: Anti-COX IV-1, Anti-Cytochrome c oxidase polypeptide IV, Anti-Cytochrome c oxidase subunit IV isoform 1, Anti-Cytochrome c oxidase subunit 4 isoform 1, mitochondrial, COX4I1 Antibody / COX IV-1
Supplier: NSJ Bioreagents
Supplier-Nr: RQ5400

Properties

Application: WB
Antibody Type: Monoclonal
Clone: AIC-3
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A synthetic peptide specific to human COX IV / COX4I1
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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