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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
C7900-76.50 | 50 µg | - | - |
3 - 19 business days* |
531.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding... more
Product information "Anti-Core Binding Factor beta (CBFb, PEBP2B)"
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit, it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. Applications: Suitable for use in Western Blot, Dot Blot and Immunocytochemistry. Other applications not tested. Recommended Dilution: Western Blot: 0.2-2ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-CBF-beta, Anti-PEA2-beta, Anti-PEBP2-beta, Anti-Core-binding factor subunit beta, Anti-SL3-3 enhancer factor 1 subunit beta, Anti-SL3/AKV core-binding factor beta subunit, Anti-Polyomavirus enhancer-binding protein 2 beta subunit |
Supplier: | United States Biological |
Supplier-Nr: | C7900-76 |
Properties
Application: | Dot Blot, ICC, WB |
Antibody Type: | Monoclonal |
Clone: | 8C84 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant hum |
Format: | Affinity Purified |
Database Information
UniProt ID : | Q13951 | Matching products |
Gene ID | GeneID 865 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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