Anti-COPS4

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA042828.25	25 µl		-		7 - 10 business days*		335.00€
ATA-HPA042828.100	100 µl		-		7 - 10 business days*		446.00€

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Protein function: Component of the COP9 signalosome complex (CSN), a complex involved in various... more

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Product information "Anti-COPS4"

Protein function: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF- type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 100% and to rat: 100%

Keywords:	Anti-SGN4, Anti-CSN4, Anti-COPS4, Anti-Signalosome subunit 4, Anti-COP9 signalosome complex subunit 4, Anti-JAB1-containing signalosome subunit 4
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA042828

Properties

Application:	ICC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: NITFEELGAL LEIPAAKAEK IASQMITEGR MNGFIDQIDG IVHFETREAL PTWDKQIQSL CFQVNNLLEK ISQTAPEWTA QAMEAQMAQ (ATA-APrEST89455)