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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
AG-25T-0116-C025 | 25 µg | - |
3 - 9 business days* |
858.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The proteolysis of collagens plays an important role in numerous physiological and pathological... more
Product information "Anti-Collagen Type 1 (3/4 fragment), pAb"
The proteolysis of collagens plays an important role in numerous physiological and pathological situations such as morphogenesis, wound healing, arthritis, arteriosclerosis and tumor metastasis. Triple helical type I collagens are made up of two alpha1 (I) and one alpha2 (I) chains, and are found in skin, tendon, ligament and interstitial tissues. Due to their fibrillary structure native collagens are resistant to most proteases. They are substrates for certain matrix metalloproteinases (MMPs), which constitute a family of zinc-dependent enzymes catalyzing the degradation of extracellular matrix components. Initial MMP-8 dependent cleavage of collagen into the characteristic 3/4 and 1/4 fragments has been shown to enable MMP-9 diffusion along the protein helix with preferential binding to the collagen 3/4 fragment tail. Finally, untwisting of the helix end results in the local denaturation of the triple helical structure. Protein function: Type I collagen is a member of group I collagen (fibrillar forming collagen). [The Uniprot Consortium]
Keywords: | Anti-COL1A1, Anti-Alpha-1 type I collagen, Anti-Collagen alpha-1(I) chain |
Supplier: | AdipoGen Life Sciences |
Supplier-Nr: | AG-25T-0116 |
Properties
Application: | ICC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | bovine, cat, bovine, dog, hamster, human, mouse, swine, rat, sheep |
Immunogen: | Synthetic peptide (human sequence) corresponding to the C-terminal end of the N-terminal three quarter collagen fragment. |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K06236 | Matching products |
UniProt ID : | P02452 | Matching products |
Gene ID | GeneID 1277 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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