Anti-cofilin1 (phospho-Tyr139)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ABE-35-1304-100	100 µg		-		3 - 11 business days*		682.00€

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Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has... more

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Product information "Anti-cofilin1 (phospho-Tyr139)"

Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Protein function: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration. [The UniProt Consortium]

Keywords:	Anti-p18, Anti-CFL, Anti-CFL1, Anti-Cofilin-1, Anti-18 kDa phosphoprotein, Anti-Cofilin, non-muscle isoform, Polyclonal Antibody to cofilin1 (phospho-Tyr139)
Supplier:	Abeomics
Supplier-Nr:	35-1304

Properties

Application:	IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Peptide sequence around phosphorylation site of tyrosine 139 (N-C-Y(p)-E-E) derived from Human cofilin.
Format:	Purified