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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay29256-100 | 100 µl | - |
6 - 10 business days* |
636.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Cofactor of BRCA1 (COBRA1), also known as negative elongation factor B (NELFB), is a 580-amino... more
Product information "Anti-COBRA1"
Cofactor of BRCA1 (COBRA1), also known as negative elongation factor B (NELFB), is a 580-amino acid nuclear protein encoded by NELFB in humans. It induces chromosome decondensation by targeting lac operator-containing chromosome regions and is a component of NELF, a four-subunit complex that suppresses RNA polymerase II elongation in vitro. COBRA1 protein levels are enriched in mammary gland luminal epithelium, and it has a role in modulating estrogen-dependent and -independent expression of oncogenes in various breast cancer cell lines. Ectopic expression or knockdown of NELFB suppresses or accelerates breast cancer cell growth, respectively, as well as enhances androgen-mediated transcription. COBRA1 also interacts with the activated protein-1 (AP-1) family members c-Jun and c-Fos, and inhibits AP-1-mediated transcription in vitro. Cayman's COBRA1 Monoclonal Antibody can be used for Western blot (WB) applications. The antibody recognizes COBRA1 at approximately 62 kDa from human, mouse, and rat samples.Synonyms: Cofactor of BRCA1, Negative Elongation Factor B, Negative Elongation Factor Complex Member B, Negative Elongation Factor Protein B, NELF-B. Immunogen: Recombinant human full-length COBRA1 expressed in E. coli. MW: ~62 kDa. Formulation: (Request formulation change), 100 µl of protein G-purified mouse monoclonal antibody. Storage Buffer: PBS with 0.05% sodium azide. Host: Mouse. Applications: WB.
Keywords: | Cofactor of BRCA1, Negative Elongation Factor B, Negative Elongation Factor Complex Member B, Negative Elongation Factor Protein B, NELF-B |
Supplier: | Cayman Chemical |
Supplier-Nr: | 29256 |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Conjugate: | No |
Host: | Mouse |
Immunogen: | Recombinant human full-length COBRA1 expressed in E. coli |
Format: | Purified |
Database Information
KEGG ID : | K15180 | Matching products |
UniProt ID : | Q8WX92 | Matching products |
Gene ID | GeneID 25920 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
H Phrases: | H402, H412 |
P Phrases: | P273, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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