Anti-CNBP

This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion from <30 repeats to 75-11000 repeats in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016], Protein function: Single-stranded DNA-binding protein that preferentially binds to the sterol regulatory element (SRE) sequence 5'-GTGCGGTG-3', and thereby mediates transcriptional repression (PubMed:2562787). Has a role as transactivator of the Myc promoter. Binds single-stranded RNA in a sequence-specific manner. [The UniProt Consortium] Recommended dilutions: WB 1:500-2000 ELISA 1:5000-20000. Cellular localization: Nucleus . Cytoplasm . Endoplasmic reticulum ., [Isoform 1]: Cytoplasm ., [Isoform 2]: Cytoplasm ., [Isoform 4]: Cytoplasm ., [Isoform 5]: Cytoplasm ., [Isoform 6]: Cytoplasm ., [Isoform 8]: Cytoplasm .