Anti-Claspin

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A300-267A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A300-267A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Required for checkpoint mediated cell cycle arrest in response to inhibition of... more

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Product information "Anti-Claspin"

Protein function: Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR- dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S- phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks. [The UniProt Consortium]

Keywords:	Anti-CLSPN, Anti-Claspin, Anti-hClaspin
Supplier:	Bethyl Laboratories
Supplier-Nr:	A300-267A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: gorilla, chimpanzee)
Immunogen:	synthetic peptide. The epitope recognized by A300-267A-T maps to a region between residues 900 and 950 of human Claspin using the numbering given in entry AAG24515.1 (GeneID 63967).
Format:	Antigen Affinity Purified