Anti-CLASP1 / CLIP-associating protein 1

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Cytoplasmic linker associated protein 1, also known as CLIP-associating protein 1 and CLASP1, is a protein which in humans is encoded by the CLASP1 gene. CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle. Protein function: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. [The UniProt Consortium]