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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
IHC-00363-T | 10 µl (2500 ng) | - |
2 - 8 business days* |
164.00€
|
|||
IHC-00363 | 100 µl (25 µg) | - |
2 - 8 business days* |
623.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Component of centriolar satellites contributing to the building of a complex... more
Product information "Anti-CEP131/AZ1 (IHC)"
Protein function: Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Acts also as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation, may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail. Required for optimal cell proliferation and cell cycle progression, may play a role in the regulation of genome stability in non- ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication. Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). [The UniProt Consortium]
Keywords: | Anti-AZI1, Anti-CEP131, Anti-Centrosomal protein of 131 kDa, Anti-5-azacytidine-induced protein 1, Anti-Pre-acrosome localization protein 1 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | IHC-00363 |
Properties
Application: | ICC-IF |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: orangutan, gorilla, chimpanzee, northern white-cheeked gibbon) |
Immunogen: | synthetic peptide. The epitope recognized by IHC-00363 maps to a region between residue 1033 and 1083 of human centrosomal protein 131 kDa (5-azacytidine induced 1) using the numbering given in entry EAW89632.1 (GeneID 22994). |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K16540 | Matching products |
UniProt ID : | Q9UPN4 | Matching products |
Gene ID | GeneID 22994 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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