Anti-CEP131/AZ1 (IHC)

Anti-CEP131/AZ1 (IHC)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
IHC-00363-T 10 µl (5+ slides) -

3 - 9 business days*

IHC-00363 100 µl (50+ slides) -

3 - 9 business days*

Protein function: Component of centriolar satellites contributing to the building of a complex... more
Product information "Anti-CEP131/AZ1 (IHC)"
Protein function: Component of centriolar satellites contributing to the building of a complex and dynamic network required to regulate cilia/flagellum formation (PubMed:17954613, PubMed:24185901). In proliferating cells, MIB1-mediated ubiquitination induces its sequestration within centriolar satellites, precluding untimely cilia formation initiation (PubMed:24121310). In contrast, during normal and ultraviolet or heat shock cellular stress-induced ciliogenesis, its non-ubiquitinated form is rapidly displaced from centriolar satellites and recruited to centrosome/basal bodies in a microtubule- and p38 MAPK-dependent manner (PubMed:24121310, PubMed:26616734). Acts also as a negative regulator of BBSome ciliary trafficking (PubMed:24550735). Plays a role in sperm flagellar formation, may be involved in the regulation of intraflagellar transport (IFT) and/or intramanchette (IMT) trafficking, which are important for axoneme extension and/or cargo delivery to the nascent sperm tail. Required for optimal cell proliferation and cell cycle progression, may play a role in the regulation of genome stability in non- ciliogenic cells (PubMed:22797915, PubMed:26297806). Involved in centriole duplication. Required for CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2 (PubMed:26297806). [The UniProt Consortium]
Keywords: Anti-AZI1, Anti-CEP131, Anti-Centrosomal protein of 131 kDa, Anti-5-azacytidine-induced protein 1, Anti-Pre-acrosome localization protein 1
Supplier: Bethyl Laboratories
Supplier-Nr: IHC-00363


Application: ICC/IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan, Gorilla, Chimpanzee, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by IHC-00363 maps to a region between residue 1033 and 1083 of human centrosomal protein 131 kDa (5-azacytidine induced 1) using the numbering given in entry EAW89632.1 (GeneID 22994).
Format: Antigen Affinity Purified

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