Anti-CEACAM 1 (Carcinoembryonic Antigen Related Cell Adhesion Molecule, BGP)

CEACAM1 (BGP) belongs to the carcinoembryonic antigen , (CEA) gene family. It is expressed on cells of epithelial and myeloid origin. CEACAM1 expression is downregulated in many tumors indicating a tumor - suppressive function. The antitumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of antiangiogenic molecules from the cells. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the iimmunoglobulin variable domains, followed by two immunoglobulin constant-like A (A1, A2) and one B domain. While the N, A1 and B domains can also be found in other CEA-family members, the A2 domain of CEACAM1 differs from those found in other CEACAM. Applications: Suitable for use in Flow Cytometry, ELISA and Immunohistochemistry. It is expected that the antibody will be suited for all applications where recognition of the native protein is required. Other applications have not tested. Recommended Dilution: ELISA: 1:200-1:400, Immunohistochemistry (Frozen): 10ug/ml , Flow Cytometry: 1.2ug/10e6 cells, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.