Anti-CDK4, clone 3F9-B12-C8

Anti-CDK4, clone 3F9-B12-C8
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG54063.100 100 µl - -

6 - 14 business days*

528.00€
 
Protein function: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and... more
Product information "Anti-CDK4, clone 3F9-B12-C8"
Protein function: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. [The UniProt Consortium]
Keywords: Anti-CDK4, Anti-PSK-J3, EC=2.7.11.22, Anti-Cyclin-dependent kinase 4, Anti-Cell division protein kinase 4
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG54063

Properties

Application: WB
Antibody Type: Monoclonal
Clone: 3F9-B12-C8
Conjugate: No
Host: Mouse
Reactivity: Human, Mouse, Rat
Immunogen: Purified recombinant human CDK4 protein fragments expressed in E.coli
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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