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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-30-1169-0.1 | 100 µg | - |
3 - 11 business days* |
594.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the... more
Product information "Anti-CD98 Monoclonal Antibody (Clone:MEM-108)"
CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the heterodimeric amino acid transporters (HATs). CD98, linked to various light chains by disulfide bond, is responsible for cell surface expression and basolateral localization of this transporter complex in polarized epithelial cells and also interacts with beta1 integrins and increases their affinity for ligand. Besides its roles in amino acid transport, CD98 is thus involved in cell fusion and activation. It is implicated in regulation of cellular differentiation, growth and apoptosis. Protein function: Sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Involved in cellular amino acid uptake. Acts as an amino acid exchanger. Involved in the transport of L-DOPA across the blood- brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Plays a role in neuronal cell proliferation (neurogenesis) in brain. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. May play an important role in high-grade gliomas. Mediates blood-to-retina L- leucine transport across the inner blood-retinal barrier which in turn may play a key role in maintaining large neutral amino acids as well as neurotransmitters in the neural retina. Acts as the major transporter of tyrosine in fibroblasts. When associated with LAPTM4B, recruits SLC3A2 and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (PubMed:25998567). [The UniProt Consortium]
Keywords: | Anti-hLAT1, Anti-4F2LC, Anti-CD98LC, Anti-SLC7A5, Anti-4F2 LC, Anti-4F2 light chain, Anti-CD98 light chain, Anti-Integral membrane protein E16, Anti-L-type amino acid transporter 1, Anti-Solute carrier family 7 member 5, Anti-CD98 Monoclonal Antibody (Clo |
Supplier: | Abeomics |
Supplier-Nr: | 30-1169 |
Properties
Application: | FC, IP, IHC |
Antibody Type: | Monoclonal |
Clone: | MEM-108 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | RAJI human Burkitt's lymphoma cell line |
Format: | Affinity Purified |
Database Information
KEGG ID : | K13780 | Matching products |
UniProt ID : | Q01650 | Matching products |
Gene ID | GeneID 8140 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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