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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-30-1720-100 | 100 tests | - |
3 - 11 business days* |
713.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR... more
Product information "Anti-CD95 / Fas Monoclonal Antibody (Clone:LT95)-APC Conjugated"
CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses. Protein function: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:9228058, PubMed:7528780, PubMed:9427603). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses. TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance. Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (PubMed:27806260). [The UniProt Consortium]
Keywords: | Anti-FASLG, Anti-APT1LG1, Anti-CD95 / Fas Monoclonal Antibody (Clone:LT95)-APC Conjugated |
Supplier: | Abeomics |
Supplier-Nr: | 30-1720 |
Properties
Application: | FC, IHC |
Antibody Type: | Monoclonal |
Clone: | LT95 |
Conjugate: | APC |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | HUT-78 human T cell lymphoma cell line |
Database Information
KEGG ID : | K04389 | Matching products |
UniProt ID : | P48023 | Matching products |
Gene ID | GeneID 356 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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